Synthesis and in-vitro antimicrobial screening of 3-cinnamoyl coumarin and 3-[3-(1H-indol-2-yl)-3-aryl-propanoyl]-2H-chromen-2-ones

Authors

Macchindra Tambe Department of Chemistry, Padmashri Vikhe Patil College, Pravaranagar (Loni Kd), Tal- Rahata, Dist -Ahmednagar, Pin-413713,(MS), India.

Somnath Gholap Department of Chemistry, Padmashri Vikhe Patil College, Pravaranagar (Loni Kd), Tal- Rahata, Dist -Ahmednagar, Pin-413713,(MS), India.

Umesh Deshmukh Department of Chemistry, Padmashri Vikhe Patil College, Pravaranagar (Loni Kd), Tal- Rahata, Dist -Ahmednagar, Pin-413713,(MS), India.

Abstract:

An efficient synthesis of some novel coumarin derivatives via 1, 4- Michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (CSA) under solvent free conditions is described. The corresponding Michael addition products were obtained in good to excellent yield. The synthesized compounds were screened for their antibacterial activity against E. coli, S. aureus and anti-fungal activity against C. albicans. All the synthesized compounds show moderate to good antimicrobial activity.

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Journal title

Iranian Journal of Catalysis

volume 3 issue 3

pages 171- 176

publication date 2013-09-01

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Keywords

Cellulose sulphonic acid(CSA) 3-acetyl coumarinn Chalcones Indole 1 4-Michael addition Antibacterial activity

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